How do I know if there's a "problem"?

"When querying agents, how do I know if there's a "problem" with my query letter, manuscript, etc.?"

I'm sure many of us have asked ourselves this; this question plagues me almost daily.

Right now, I'm querying a graphic novel, which already happens to be a medium with a lack of standardization when it comes to querying or getting published. I've had several beta reviewers go through it, had a professional editor who I have a lot of respect for dissect it (as well as review my query...

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